Semaglutide or Tirzepatide? How to Choose With Your Provider
5 min read
They're the two biggest names in weight loss right now, and for good reason. Semaglutide and tirzepatide have helped people lose weight that wouldn't budge for years. Both are once-a-week injections. Both quiet hunger and cravings. So which one is right for you? Here's everything you need to know.
One pathway or two
Semaglutide works on GLP-1, the hormone that tells your brain you're full.
Tirzepatide works on GLP-1 and GIP, a second hormone that also helps control appetite and blood sugar.
That dual action is a big reason tirzepatide has produced some of the most impressive weight loss results ever seen in clinical trials.
Side by side
Semaglutide | Tirzepatide | |
|---|---|---|
How it works | GLP-1 | GLP-1 + GIP (dual action) |
How often | Once a week | Once a week |
Average weight loss in major trials | About 15% of body weight (STEP 1) | Up to about 21% of body weight (SURMOUNT-1) |
For a 200-lb person, that's about | 30 lbs | 40+ lbs |
Only Human price | $199/month | $299/month |
In a 2025 head-to-head clinical trial (SURMOUNT-5), people taking tirzepatide lost significantly more weight on average than those taking semaglutide. Both medications, though, delivered results most people only dream about.
Why people choose semaglutide
Proven track record: it's been used and studied by millions of people.
Powerful results: about 15% average weight loss in its landmark trial.
Lower price: at $199/month, it's a strong value for serious results.
Why people choose tirzepatide
Dual action: two hormone pathways working together.
The biggest average results: up to about 21% average weight loss in trials.
A step up: a popular choice for people who want maximum support, or who've plateaued on semaglutide.
Let your provider help you decide
The best choice depends on you. Your provider will look at:
Your goals: how much weight you want to lose.
Your health history: conditions, medications, and past treatments.
Your budget: both are affordable, with no hidden fees.
Your experience: if you've taken one before, your provider may suggest continuing or switching.
Can you switch later?
Absolutely. Many people start with semaglutide and move to tirzepatide for an extra boost, or the other way around. Your provider will guide any switch safely.
Either way, you're choosing a breakthrough
Whichever you choose, you're getting one of the most effective weight loss tools medicine has ever produced, with a licensed provider in your corner and no insurance required.
Ready to find your match? Complete your free health questionnaire, and a licensed provider will help you decide. Explore Compounded Semaglutide or Compounded Tirzepatide.
Sources: Wilding et al. (STEP 1), New England Journal of Medicine, 2021. Jastreboff et al. (SURMOUNT-1), New England Journal of Medicine, 2022. Aronne et al., “Tirzepatide as Compared with Semaglutide for the Treatment of Obesity” (SURMOUNT-5), New England Journal of Medicine, 2025.
Ready to take the next step?
Compounded Tirzepatide
This article is for educational purposes only and is not medical advice. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety or effectiveness. Talk with a licensed provider before starting any treatment.
