Patch, gel, tablet or cream
Estradiol
From $70/mo
Hot flashes, night sweats & vaginal dryness
Actual prescription vial and label appearance will vary.
Some forms are compounded. Compounded medications are not FDA-approved.
Actual prescription vial and label appearance will vary.
Progesterone · Menopause
Rest easier through the change.
Progesterone balances estrogen’s effect on the uterine lining and has a calming effect that can help with sleep. For women who still have a uterus, it’s usually prescribed alongside estrogen, only if a licensed provider decides it’s right for you. Results vary.
Get startedFrom $70/month
Some forms are compounded. Compounded medications are not FDA-approved. A licensed provider decides if treatment is right for you.
Actual prescription vial and label appearance will vary.
OnlyHuman Rx / Menopause
Capsule or cream · Provider-guided care
Progesterone
From $70/month
Progesterone balances estrogen's effect on the uterine lining and has a calming effect that can help with sleep. It's usually prescribed alongside estrogen for women who still have a uterus.
Some forms are compounded. Compounded medications are not FDA-approved.
No insurance requiredNo membership or hidden feesUnlimited support
Save 10% with a 3-month plan
Plans from $70, $95 or $125 a month, depending on what your provider prescribes. Compare plansStart Today · From $70/mo
Free online visit · You’re not charged unless a provider prescribes
What is progesterone?
Progesterone is a hormone the ovaries make after ovulation, in the second half of the menstrual cycle. It balances estrogen's effect on the uterine lining, helps regulate periods, and has a calming effect that can help with sleep. During perimenopause, progesterone is often the first hormone to drop, which can cause irregular periods, poor sleep and anxiety.
Forms
- Capsules (micronized progesterone): FDA-approved and bioidentical, usually taken at bedtime because they can cause drowsiness. This is the standard choice for protecting the uterus.
- Cream: Usually compounded and applied to the skin. It absorbs less predictably, and major menopause medical societies don't consider it reliable for protecting the uterus with estrogen therapy. Compounded medications are not FDA-approved.
Subject to medical approval. A prescription is required. Final eligibility is determined online by a licensed healthcare provider.
Pay over time with Klarna · Affirm · Afterpay
FSA/HSA eligibility and coverage varies by plan provider.
Benefits
The quiet partner to estrogen therapy, usually taken at bedtime.
Get started
Protects the Uterus
For women who still have one, progesterone is usually prescribed alongside estrogen to keep the uterine lining from thickening.
Sleep Support
Taken at bedtime, it can help some women fall asleep and stay asleep more easily.
A Calmer Evening
Progesterone has a calming effect, which is part of why capsules are usually taken at bedtime.
Perimenopause Support
Progesterone is often the first hormone to drop, which can mean irregular periods, poor sleep and anxiety. Your provider can tell you if it's right for you.
Results vary. Treatment works best alongside balanced meals, movement, and sleep.
How it works
- 01
Online Intake
Choose a program and answer a short online health questionnaire. It’s free and only takes a few minutes.
- 02
Provider Review
A licensed provider reviews your answers and health history to decide whether treatment is right for you.
- 03
Delivered to Your Door
If prescribed, your medication is prepared by a licensed pharmacy and shipped to you in discreet packaging.
The Health Guide
OnlyHuman Health Guide
Real answers for your health journey.
View allRelated treatments
View MenopauseCompounded blend
Biest 50:50
Estradiol + estriol, customized for you
Actual prescription vial and label appearance will vary.
Some forms are compounded. Compounded medications are not FDA-approved.
Injectable
Sermorelin
$149/mo
Sleep, recovery & healthy aging
Actual prescription vial and label appearance will vary.
Your questions, answered
Frequently asked questions.
What is progesterone?
Progesterone is a hormone the ovaries make after ovulation, in the second half of the menstrual cycle. It balances estrogen's effect on the uterine lining, helps regulate periods, and has a calming effect that can help with sleep. During perimenopause, progesterone is often the first hormone to drop, which can cause irregular periods, poor sleep and anxiety.
How is progesterone used in menopause?
As a menopause treatment, progesterone has two main uses:
- Protecting the uterus. For women who still have one, estrogen alone can thicken the uterine lining and raise the risk of endometrial cancer. Progesterone prevents that, so it's usually prescribed alongside estrogen.
- Sleep and calm. Taken at bedtime, it can help some women fall asleep and stay asleep more easily.
What forms does progesterone come in?
- Capsules (micronized progesterone): FDA-approved and bioidentical, usually taken at bedtime because they can cause drowsiness. This is the standard choice for protecting the uterus.
- Cream: Usually compounded and applied to the skin. It absorbs less predictably, and major menopause medical societies don't consider it reliable for protecting the uterus with estrogen therapy. Compounded medications are not FDA-approved.
Is progesterone cream FDA-approved?
No. Progesterone cream is usually compounded, and compounded medications are not FDA-approved. Micronized progesterone capsules are FDA-approved and are the standard choice for protecting the uterus.
Can I take progesterone with my other medications?
List all medications and supplements in your intake. A licensed provider will review them before prescribing.