Capsule or cream
Progesterone
From $70/mo
Uterine protection & better sleep
Actual prescription vial and label appearance will vary.
Some forms are compounded. Compounded medications are not FDA-approved.
Actual prescription vial and label appearance will vary.
Estradiol · Menopause
Feel more like you, in every season.
Estradiol is a bioidentical form of estrogen, the hormone your ovaries make less of during menopause. Prescribed only if a licensed provider decides it’s right for you, it replaces what your body no longer makes to ease symptoms like hot flashes, night sweats and vaginal dryness. Results vary.
Get startedFrom $70/month
Some forms are compounded. Compounded medications are not FDA-approved. A licensed provider decides if treatment is right for you.
Actual prescription vial and label appearance will vary.
OnlyHuman Rx / Menopause
Patch, gel, tablet or cream · Provider-guided care
Estradiol
From $70/month
Estradiol is a bioidentical form of estrogen, the hormone your ovaries make less of during menopause. It replaces what the body no longer makes, to ease symptoms like hot flashes, night sweats and vaginal dryness.
Some forms are compounded. Compounded medications are not FDA-approved.
No insurance requiredNo membership or hidden feesUnlimited support
Save 10% with a 3-month plan
Plans from $70, $95 or $125 a month, depending on what your provider prescribes. Compare plansStart Today · From $70/mo
Free online visit · You’re not charged unless a provider prescribes
What is estradiol?
Estradiol is the main form of estrogen the body makes. During a woman's reproductive years it's produced mostly by the ovaries, and it's the strongest of the body's three natural estrogens. It plays a role in:
- Regulating the menstrual cycle
- Keeping body temperature steady, which is why low levels cause hot flashes
- Protecting bone density
- Supporting vaginal and urinary tissue
- Skin, hair, mood, sleep and memory
During menopause, the ovaries make much less estradiol. That drop causes most menopause symptoms.
Forms
FDA-approved estradiol comes as patches, gels, sprays, tablets, vaginal creams, vaginal inserts and vaginal rings. Your provider will help you choose the form that fits you.
- Patch: A small adhesive patch worn on the lower belly or hip and changed once or twice a week. It releases a steady dose through the skin, with nothing to remember daily.
- Gel: A measured amount rubbed onto the arm or thigh once a day. It dries quickly and absorbs through the skin.
- Tablet: A daily pill swallowed by mouth. It's simple and familiar, and usually the most affordable option.
- Body cream: Usually compounded. It's applied to the skin daily, and the dose can be customized by the provider. Compounded products are not FDA-approved.
For vaginal and urinary symptoms (dryness, discomfort with sex, urinary urgency):
- Vaginal cream: Applied inside the vagina with an applicator, usually daily at first and then a few times a week.
Subject to medical approval. A prescription is required. Final eligibility is determined online by a licensed healthcare provider.
Pay over time with Klarna · Affirm · Afterpay
FSA/HSA eligibility and coverage varies by plan provider.
Benefits
Relief for the symptoms that get in the way, with a licensed provider guiding the form and dose.
Get started
Hot Flashes and Night Sweats
Estradiol helps keep body temperature steady. Replacing what your body no longer makes can ease hot flashes and night sweats.
Sleep, Mood and Memory
Estrogen plays a role in sleep, mood and memory, so your provider looks at the whole picture, not just one symptom.
Vaginal and Urinary Comfort
Vaginal estradiol cream is used for dryness, discomfort with sex and urinary urgency.
A Form That Fits Your Life
Patch, gel, tablet or cream. Your provider helps you choose the form and dose that fit your routine.
Results vary. Treatment works best alongside balanced meals, movement, and sleep.
How it works
- 01
Online Intake
Choose a program and answer a short online health questionnaire. It’s free and only takes a few minutes.
- 02
Provider Review
A licensed provider reviews your answers and health history to decide whether treatment is right for you.
- 03
Delivered to Your Door
If prescribed, your medication is prepared by a licensed pharmacy and shipped to you in discreet packaging.
The Health Guide
OnlyHuman Health Guide
Real answers for your health journey.
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Your questions, answered
Frequently asked questions.
What is estradiol?
Estradiol is the main form of estrogen the body makes. During a woman's reproductive years it's produced mostly by the ovaries, and it's the strongest of the body's three natural estrogens. It plays a role in:
- Regulating the menstrual cycle
- Keeping body temperature steady, which is why low levels cause hot flashes
- Protecting bone density
- Supporting vaginal and urinary tissue
- Skin, hair, mood, sleep and memory
During menopause, the ovaries make much less estradiol. That drop causes most menopause symptoms.
Is estradiol bioidentical?
As a medication, estradiol is chemically identical to the estradiol your body makes, so it's considered "bioidentical." It replaces what the body no longer makes, to ease symptoms like hot flashes, night sweats and vaginal dryness.
What forms does estradiol come in?
FDA-approved estradiol comes as patches, gels, sprays, tablets, vaginal creams, vaginal inserts and vaginal rings. Your provider will help you choose the form that fits you.
- Patch: A small adhesive patch worn on the lower belly or hip and changed once or twice a week. It releases a steady dose through the skin, with nothing to remember daily.
- Gel: A measured amount rubbed onto the arm or thigh once a day. It dries quickly and absorbs through the skin.
- Tablet: A daily pill swallowed by mouth. It's simple and familiar, and usually the most affordable option.
- Body cream: Usually compounded. It's applied to the skin daily, and the dose can be customized by the provider. Compounded products are not FDA-approved.
For vaginal and urinary symptoms (dryness, discomfort with sex, urinary urgency):
- Vaginal cream: Applied inside the vagina with an applicator, usually daily at first and then a few times a week.
Do I need progesterone with estradiol?
For women who still have a uterus, estrogen alone can thicken the uterine lining and raise the risk of endometrial cancer. Progesterone prevents that, so it's usually prescribed alongside estrogen. Your provider will decide what's right for you.
Is compounded estradiol FDA-approved?
No. Compounded products, like estradiol body cream, are not FDA-approved. Every prescription is written only after a licensed provider reviews your health history, symptoms and goals. A licensed provider decides if treatment is right for you.